Humans have long sought to transform nature, using tools to modify the environment around us or enhancing our own bodies to adapt in this world. Technology today continues to open up new spaces for transformative and transcendent experiences of life itself. From AI to augmented reality displays, with cloning and human genetic engineering, through organ transplants and prosthetics, emerging technologies are expanding many of our intellectual, physical, and psychological capacities. Transhumanism is a movement to overcome fundamental human limitations. A conversation around this ambition is crucial to understanding emergent culture today and our science-fiction future.